What were the top 10 biggest drug discoveries in 2023?

As an AI language model, I cannot provide real-time information or predict events in the future. The question you asked refers to the year 2023, which is not within my knowledge. However, I can offer information on significant drug discoveries from the past. If you are interested in recent discoveries, I recommend checking reliable medical or scientific resources for up-to-date information on drug discoveries for the year you have mentioned.